Garlic Alfredo Tilapia

Garlic Alfredo Tilapia

Made  times
youngwoman 13

"My version of Ruby Tuesday's New Orleans Seafood, minus the shrimp. I merged a few different recipes and came up with this. It comes pretty close! Three fillets are usually enough for my husband, my toddler, and myself. I serve this with rice and steamed broccoli, to really feel like Ruby Tuesday's recipe!"
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25 m servings 435 cals
Serving size has been adjusted!

Original recipe yields 4 servings



  • Calories:
  • 435 kcal
  • 22%
  • Fat:
  • 35 g
  • 54%
  • Carbs:
  • 4.4g
  • 1%
  • Protein:
  • 26.3 g
  • 53%
  • Cholesterol:
  • 89 mg
  • 30%
  • Sodium:
  • 1089 mg
  • 44%

Based on a 2,000 calorie diet

See full nutrition

Nutritional Information

1 Serving
Servings Per Recipe:
Amount Per Serving
  • * Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
  • ** Nutrient information is not available for all ingredients. Amount is based on available nutrient data.
  • (-) Information is not currently available for this nutrient. If you are following a medically restrictive diet, please consult your doctor or registered dietitian before preparing this recipe for personal consumption.


  • Prep

  • Cook

  • Ready In

  1. Preheat an oven to 425 degrees F (220 degrees C).
  2. Brush the tilapia fillets with oil on both sides, season with Creole seasoning to taste, then place into a 9x13-inch baking dish.
  3. Bake in the preheated oven until the flesh is no longer translucent, and the fish flakes easily with a fork, about 10 minutes.
  4. Meanwhile, melt the butter in a small saucepan over medium heat. Stir in the garlic, and cook until the garlic has softened and the aroma has mellowed, about 2 minutes. Stir in the Alfredo sauce and bring to a simmer. Reduce the heat to low, and keep warm until the fish is ready. Pour the sauce over the fish to serve. Sprinkle with additional Creole seasoning if desired.


  • Tip
  • Aluminum foil can be used to keep food moist, cook it evenly, and make clean-up easier.


  1. 360 Ratings

Most helpful positive review

This is a simple yet delicious way to serve Tilapia! I had my dinner ready in about 15 minutes...which is amazing for me! I season my fillets with either Penzey's Northwoods Seasoning or Penze...

Most helpful critical review

I liked the fact that the recipe is easy with ingredients found readily at home. I thought it tasted good, but not great.

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Least positive

This is a simple yet delicious way to serve Tilapia! I had my dinner ready in about 15 minutes...which is amazing for me! I season my fillets with either Penzey's Northwoods Seasoning or Penze...

This recipe is FANTASTIC. I'm sure it's wonderful with the Creole seasoning but I can't eat spicy food so I used Johnny's Seasoning instead. When the sauteed garlic was just right I added some...

Out of the 10 recipes I have tried on this site this is my favorite. I used the roasted red pepper alfredo instead of regular alfredo and it was amazing.

OMG...this just works!!! I was a bit hesitant to top my beloved tilapia with alfredo sauce. I am so glad I did as it takes it from wonderful to amazing! I bake my tilapia the same way, but ha...

i used to work at ruby tuesday so i have had the new orleans seafood many many times! and have served it 100s of times. and this looked and tasted so much like it. it was delicious!! and really ...

Very Very Tasty! I did make my own alfredo sauce for this because jared ones are just not very good. This was gobbled up by all three of my children. It has been put on the "make again" list!

I was a little worried about the alfredo with fish, but it was de-lish! Wish I had some broccoli or asparagas to go with it though, I think that would have really complimented the dish!! Thank...

We eat a lot of Tilapia and were growing bored with the same style over and over again. When searching for a different taste, I decided to give this recipe a try and it was wonderful. We will ...

So simple and so good. The alredo sauce and spicy seasoning nicely offset each other. Huge hit w/ the fam.

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